Health & Living

Genome sequencing for all worldwide sufferers who check optimistic for Covid-19: why is it obligatory?

As concern of the brand new pressure of coronavirus grips India, the middle has launched new pointers for COVID-19 surveillance that may stay in impact till January 31. It famous that though there was a unbroken decline in lively and new circumstances of COVID-19, there’s a want to keep up surveillance, containment and warning, considering the surge in circumstances world wide and the emergence of a brand new variant of the virus within the UK. In the meantime, the Union Division of Well being introduced that each one worldwide passengers who arrived in India within the final fortnight earlier than the UK journey ban (i.e. between 9 and December 22) will bear genome sequencing if they’re symptomatic and check optimistic for Covid-19. . Learn additionally – New COVID-19 mutations can escape antibodies and cause reinfection; Here’s what you need to know

Per week in the past, the Division of Well being introduced the sequencing of all passengers arriving from the UK. Learn additionally – Beware: Common Diabetic Drug May Trigger Rare Complications Of COVID-19

India had imposed a short lived suspension on flights from the UK following reviews of the emergence of a brand new pressure of extremely infectious coronavirus in Britain. The flight suspension that got here into impact from midnight on December 22 will proceed till December 31. The ban could possibly be additional prolonged given the present state of affairs, the Union Minister of Civil Aviation mentioned at present. Passengers arriving from the UK had been additionally subjected to a compulsory RT-PCR check upon arrival at affected airports. Learn additionally – New “ highly contagious ” Covid-19 variant present in Germany since November

What’s genome sequencing?

Genome sequencing is the method of figuring out the whole DNA sequence of an organism’s genome. This includes figuring out the order of DNA nucleotides, or bases, in a genome – the order of the As, Cs, Gs and Ts that make up the DNA of an organism. For instance, the human genome is made up of over 3 billion of those genetic letters.

Figuring out your complete genome sequence will help scientists perceive how genes work collectively to direct the expansion, growth, and upkeep of a whole organism.

Researchers consider that genetic sequencing will help monitor COVID-19 mutations, which in flip will help enhance diagnostic testing and transmission monitoring.

Most assessments developed for COVID-19 search for a part of the sequence of the gene that causes the virus, but when that sequence mutates, the check is not correct – a examine revealed in Cell Experiences famous.

“It’s inherent within the nature of a virus to mutate. Adjustments in different areas of the genetic sequence can’t solely disrupt testing, however hinder the effectiveness of vaccines, ”mentioned Dirk Dittmer, PhD, professor of microbiology and immunology at UNC Faculty of Medication. and lead writer of the examine.

The examine means that next-generation sequencing might assist enhance the accuracy of diagnostic assessments.

17 mutations present in newest COVID-19 pressure

British scientists have discovered 17 adjustments or mutations within the newest variant, named VUI 202012/01 (the primary variant below investigation in December 2020). In keeping with them, probably the most essential mutations is the “N501Y” mutation within the spike protein that the virus makes use of to bind to the human ACE2 receptor. It’s believed that adjustments on this a part of the spike protein are liable for the virus turning into extra infectious and spreading simply and rapidly amongst people. The British authorities had mentioned the brand new variant was as much as 70% extra infectious than earlier strains.

To detect the brand new pressure of coronavirus in India, the middle has recognized 10 regional labs the place states will ship 5 % of their Covid-19 optimistic samples for genome sequencing.

The Division of Well being has additionally established the Indian SARS-CoV-2 Genomics Consortium (INSACOG) for laboratory and epidemiological surveillance and to develop complete genome sequencing of the coronavirus within the nation.

The generated viral genome sequencing information will likely be analyzed by the respective facilities and despatched to the Nationwide Middle for Illness Management (NCDC), Delhi, for collation and integration, in line with the Ministry of Well being pointers on genomic sequencing launched on Monday.

This can assist perceive super-spreading occasions and epidemics and strengthen public well being interventions throughout the nation to assist break chains of transmission, the ministry mentioned.

In the meantime, India reported six circumstances of the brand new pressure of Covid-19 on Tuesday. In keeping with a authorities assertion, three samples in NIMHANS of Bengaluru, two in CCMB, Hyderabad and one in NIV, Pune have examined optimistic for the mutant pressure of the Covid-19 virus. All of the sufferers had not too long ago returned from Nice Britain.

Posted: Dec 29, 2020 7:06 PM

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